Version 5.4
Bos taurus Protein: BT.19261
Summary
InnateDB Protein IDBP-692673.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.19261
Protein Name transcription factor SOX-18
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015485
InnateDB Gene IDBG-640416 (BT.19261)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0001942 hair follicle development
GO:0001944 vasculature development
GO:0001945 lymph vessel development
GO:0001946 lymphangiogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0007507 heart development
GO:0022405 hair cycle process
GO:0035050 embryonic heart tube development
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0043534 blood vessel endothelial cell migration
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0048866 stem cell fate specification
GO:0060214 endocardium formation
GO:0060836 lymphatic endothelial cell differentiation
GO:0060956 endocardial cell differentiation
GO:0061028 establishment of endothelial barrier
GO:0072091 regulation of stem cell proliferation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0044798 nuclear transcription factor complex
Protein Structure and Domains
PDB ID
InterPro IPR009071 High mobility group box domain
IPR021934 Sox C-terminal transactivation domain
PFAM PF00505
PF09011
PF12067
PRINTS
PIRSF
SMART SM00398
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F6RRS7
UniProt Splice Variant
Entrez Gene 519439
UniGene Bt.19261
RefSeq NP_001069257
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02036215 DAAA02036216
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca