InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PRMT2

Summary

InnateDB Protein

IDBP-692684.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT2

Protein Name

protein arginine methyltransferase 2

Synonyms

HRMT1L1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000031501

InnateDB Gene

IDBG-640417 (PRMT2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0030331	estrogen receptor binding
GO:0033142	progesterone receptor binding
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0042803	protein homodimerization activity
GO:0042974	retinoic acid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0046966	thyroid hormone receptor binding
GO:0050681	androgen receptor binding

Biological Process

GO:0006479	protein methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032259	methylation
GO:0034969	histone arginine methylation
GO:0043065	positive regulation of apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060765	regulation of androgen receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001452 SH3 domain
IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR011511 Variant SH3 domain
IPR025799 Protein arginine N-methyltransferase

PFAM

PF00018
PF14604
PF05175
PF06325
PF07653
PF05185

PRINTS

PR00452

PIRSF

SMART

SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q3MHV5

UniProt Splice Variant

Entrez Gene

507839

UniGene

Bt.59472

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC104629 DAAA02003520

GenPept

AAI04630