Version 5.4
Bos taurus Protein: PTPRF
Summary
InnateDB Protein IDBP-692697.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRF
Protein Name Receptor-type tyrosine-protein phosphatase F
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024046
InnateDB Gene IDBG-640420 (PTPRF)
Protein Structure
UniProt Annotation
Function Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity). {ECO:0000250}.The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. {ECO:0000250}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0032403 protein complex binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007155 cell adhesion
GO:0016311 dephosphorylation
GO:0016477 cell migration
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:1900121 negative regulation of receptor binding
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
PFAM PF00102
PF00041
PF01108
PF07679
PRINTS PR00700
PIRSF
SMART SM00194
SM00404
SM00408
SM00409
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A7MBJ4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 512072
UniGene Bt.5379
RefSeq NP_001094549
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151592
GenPept AAI51593

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca