Version 5.4
Bos taurus Protein: BECN1
Summary
InnateDB Protein IDBP-692718.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BECN1
Protein Name Beclin-1
Synonyms ATG6;
Species Bos taurus
Ensembl Protein ENSBTAP00000026531
InnateDB Gene IDBG-640456 (BECN1)
Protein Structure
UniProt Annotation
Function Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Interaction with KIAA0831/Barkor promotes translocation to autophagosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000910 cytokinesis
GO:0006914 autophagy
GO:0007049 cell cycle
GO:0051301 cell division
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR007243 Atg6/Beclin
PFAM PF04111
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4A1L4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 527278
UniGene Bt.106861
RefSeq NP_001028799
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AM051355 BC102177
GenPept AAI02178 CAJ19744

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca