InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: TIE1

Summary

InnateDB Protein

IDBP-692763.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIE1

Protein Name

tyrosine-protein kinase receptor Tie-1 precursor

Synonyms

TIE;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004917

InnateDB Gene

IDBG-640485 (TIE1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001568	blood vessel development
GO:0001701	in utero embryonic development
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0016525	negative regulation of angiogenesis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030336	negative regulation of cell migration
GO:0032526	response to retinoic acid
GO:0045026	plasma membrane fusion

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000742 Epidermal growth factor-like domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00008
PF07714
PF00041
PF01108

PRINTS

PR00109

PIRSF

SMART

SM00181
SM00220
SM00409
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt