Version 5.4
Bos taurus Protein: NSMCE4A
Summary
InnateDB Protein IDBP-692768.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSMCE4A
Protein Name Non-structural maintenance of chromosomes element 4 homolog A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000025508
InnateDB Gene IDBG-640495 (NSMCE4A)
Protein Structure
UniProt Annotation
Function Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:2001022 positive regulation of response to DNA damage stimulus
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005694 chromosome
GO:0030915 Smc5-Smc6 complex
Protein Structure and Domains
PDB ID
InterPro IPR014854 Non-structural maintenance of chromosome element 4, C-terminal
PFAM PF08743
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2TBI1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 527312
UniGene Bt.30543
RefSeq NP_001033767
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC110171
GenPept AAI10172

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca