Version 5.4
Bos taurus Protein: HLCS
Summary
InnateDB Protein IDBP-692799.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLCS
Protein Name holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000051848
InnateDB Gene IDBG-640520 (HLCS)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity
GO:0004080 biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
GO:0005515 protein binding
GO:0009374 biotin binding
GO:0018271 biotin-protein ligase activity
GO:0019899 enzyme binding
Biological Process
GO:0006464 cellular protein modification process
GO:0008283 cell proliferation
GO:0009305 protein biotinylation
GO:0016570 histone modification
GO:0070781 response to biotin
GO:0071110 histone biotinylation
Cellular Component
GO:0000785 chromatin
GO:0005652 nuclear lamina
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016363 nuclear matrix
Protein Structure and Domains
PDB ID
InterPro IPR003142 Biotin protein ligase, C-terminal
IPR004143 Biotin/lipoate A/B protein ligase
IPR004408 Biotin--acetyl-CoA-carboxylase ligase
PFAM PF02237
PF03099
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MJL3
UniProt Splice Variant
Entrez Gene 534247
UniGene Bt.44778
RefSeq XP_002685200
HUGO HGNC:4976
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003572 DAAA02003573 DAAA02003574
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca