InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ACTL6B

Summary

InnateDB Protein

IDBP-692811.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACTL6B

Protein Name

Actin-like protein 6B

Synonyms

BAF53B;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010915

InnateDB Gene

IDBG-640534 (ACTL6B)

Protein Structure

UniProt Annotation

Function

Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0016568	chromatin modification

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016514	SWI/SNF complex
GO:0071565	nBAF complex

Protein Structure and Domains

PDB ID

InterPro

IPR004000 Actin-related protein

PFAM

PF00022

PRINTS

PR00190

PIRSF

SMART

SM00268

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A4FUX8

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

504476

UniGene

Bt.8753

RefSeq

NP_001076839

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123419

GenPept

AAI23420