Version 5.4
Bos taurus Protein: ZGPAT
Summary
InnateDB Protein IDBP-692821.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZGPAT
Protein Name Zinc finger CCCH-type with G patch domain-containing protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000042610
InnateDB Gene IDBG-640545 (ZGPAT)
Protein Structure
UniProt Annotation
Function Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000467 G-patch domain
IPR000571 Zinc finger, CCCH-type
PFAM PF01585
PF00642
PRINTS
PIRSF
SMART SM00443
SM00356
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q17QX2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 510866
UniGene Bt.22848
RefSeq NP_001019685
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118131
GenPept AAI18132

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca