Version 5.4
Bos taurus Protein: RPL13A
Summary
InnateDB Protein IDBP-692845.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPL13A
Protein Name 60S ribosomal protein L13a
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000040732
InnateDB Gene IDBG-640566 (RPL13A)
Protein Structure
UniProt Annotation
Function Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0006417 regulation of translation
GO:0017148 negative regulation of translation
GO:1901194 negative regulation of formation of translation preinitiation complex
Cellular Component
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0097452 GAIT complex
Protein Structure and Domains
PDB ID
InterPro IPR005755 Ribosomal protein L13, eukaryotic/archaeal
IPR005822 Ribosomal protein L13
IPR023564 Ribosomal protein L13 domain
PFAM PF00572
PRINTS
PIRSF PIRSF002181
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SZ90
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 767925
UniGene
RefSeq NP_001070466
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103039
GenPept AAI03040

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca