Version 5.4
Bos taurus Protein: NOTCH1
Summary
InnateDB Protein IDBP-692873.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NOTCH1
Protein Name Notch gene homolog 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017746
InnateDB Gene IDBG-640538 (NOTCH1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 182 interaction(s) predicted by orthology.
Predicted by orthology
Total 182 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004857 enzyme inhibitor activity
GO:0004872 receptor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0031490 chromatin DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0001947 heart looping
GO:0002040 sprouting angiogenesis
GO:0002437 inflammatory response to antigenic stimulus
GO:0003157 endocardium development
GO:0003160 endocardium morphogenesis
GO:0003162 atrioventricular node development
GO:0003169 coronary vein morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003192 mitral valve formation
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003207 cardiac chamber formation
GO:0003208 cardiac ventricle morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003213 cardiac right atrium morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003219 cardiac right ventricle formation
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003241 growth involved in heart morphogenesis
GO:0003256 regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003270 Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
GO:0003273 cell migration involved in endocardial cushion formation
GO:0003344 pericardium morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006959 humoral immune response
GO:0007219 Notch signaling pathway
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007275 multicellular organismal development
GO:0007368 determination of left/right symmetry
GO:0007386 compartment pattern specification
GO:0007409 axonogenesis
GO:0007440 foregut morphogenesis
GO:0007492 endoderm development
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008544 epidermis development
GO:0009912 auditory receptor cell fate commitment
GO:0010001 glial cell differentiation
GO:0010468 regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010832 negative regulation of myotube differentiation
GO:0014031 mesenchymal cell development
GO:0014807 regulation of somitogenesis
GO:0021915 neural tube development
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0030279 negative regulation of ossification
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030900 forebrain development
GO:0031069 hair follicle morphogenesis
GO:0032495 response to muramyl dipeptide
GO:0035116 embryonic hindlimb morphogenesis
GO:0035148 tube formation
GO:0035914 skeletal muscle cell differentiation
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0042640 anagen
GO:0043065 positive regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0045165 cell fate commitment
GO:0045596 negative regulation of cell differentiation
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046533 negative regulation of photoreceptor cell differentiation
GO:0048103 somatic stem cell division
GO:0048663 neuron fate commitment
GO:0048711 positive regulation of astrocyte differentiation
GO:0048715 negative regulation of oligodendrocyte differentiation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050767 regulation of neurogenesis
GO:0050768 negative regulation of neurogenesis
GO:0050793 regulation of developmental process
GO:0055008 cardiac muscle tissue morphogenesis
GO:0060038 cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060253 negative regulation of glial cell proliferation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060548 negative regulation of cell death
GO:0060740 prostate gland epithelium morphogenesis
GO:0060768 regulation of epithelial cell proliferation involved in prostate gland development
GO:0060842 arterial endothelial cell differentiation
GO:0060843 venous endothelial cell differentiation
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060956 endocardial cell differentiation
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0060982 coronary artery morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0061384 heart trabecula morphogenesis
GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070986 left/right axis specification
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0072017 distal tubule development
GO:0072044 collecting duct development
GO:0072144 glomerular mesangial cell development
GO:0072602 interleukin-4 secretion
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097150 neuronal stem cell maintenance
GO:1901201 regulation of extracellular matrix assembly
GO:1902263 apoptotic process involved in embryonic digit morphogenesis
GO:2000737 negative regulation of stem cell differentiation
GO:2000811 negative regulation of anoikis
GO:2000974 negative regulation of pro-B cell differentiation
GO:2001027 negative regulation of endothelial cell chemotaxis
Cellular Component
GO:0002193 MAML1-RBP-Jkappa- ICN1 complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID
InterPro IPR000742 Epidermal growth factor-like domain
IPR000800 Notch domain
IPR001881 EGF-like calcium-binding domain
IPR002110 Ankyrin repeat
IPR008297 Notch
IPR010660 Notch, NOD domain
IPR011656 Notch, NODP domain
IPR013111 EGF-like domain, extracellular
IPR020683 Ankyrin repeat-containing domain
IPR022362 Neurogenic locus Notch 1
IPR024600 Domain of unknown function DUF3454, notch
PFAM PF00008
PF00066
PF07645
PF00023
PF13606
PF06816
PF07684
PF07974
PF11929
PF12796
PF11936
PRINTS PR01452
PR01415
PR01984
PIRSF PIRSF002279
SMART SM00181
SM00004
SM00179
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3MU93
UniProt Splice Variant
Entrez Gene 767866
UniGene Bt.53527
RefSeq XP_002691666
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB235416 DAAA02032322 DAAA02032323 DAAA02032324 DAAA02032325
GenPept BAE44528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca