InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDK1

Summary

InnateDB Protein

IDBP-692885.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDK1

Protein Name

pyruvate dehydrogenase kinase, isozyme 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000038331

InnateDB Gene

IDBG-640584 (PDK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0008283	cell proliferation
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010906	regulation of glucose metabolic process
GO:0097411	hypoxia-inducible factor-1alpha signaling pathway

Cellular Component

GO:0005739	mitochondrion
GO:0005967	mitochondrial pyruvate dehydrogenase complex

Protein Structure and Domains

PDB ID

InterPro

IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR005467 Signal transduction histidine kinase, core
IPR018955 Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal

PFAM

PF02518
PF13581
PF10436

PRINTS

PIRSF

SMART

SM00387

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite