InnateDB Protein
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IDBP-692900.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MED22
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Protein Name
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Mediator of RNA polymerase II transcription subunit 22
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Synonyms
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SURF5;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000015357
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InnateDB Gene
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IDBG-640610 (MED22)
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Protein Structure
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Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
30 [view]
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Molecular Function |
Accession |
GO Term |
GO:0001104
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RNA polymerase II transcription cofactor activity
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GO:0005515
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protein binding
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006366
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transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR009332
Mediator complex, subunit Med22
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PFAM |
PF06179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5E9K2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
613736
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UniGene |
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RefSeq |
NP_001029914
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC148153
BT020918
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GenPept |
AAI48154
AAX08935
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