InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: VWF

Summary

InnateDB Protein

IDBP-692911.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VWF

Protein Name

von Willebrand factor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000016273

InnateDB Gene

IDBG-640531 (VWF)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0002020	protease binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0019865	immunoglobulin binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0047485	protein N-terminus binding
GO:0051087	chaperone binding

Biological Process

GO:0001889	liver development
GO:0001890	placenta development
GO:0007596	blood coagulation
GO:0007599	hemostasis
GO:0030168	platelet activation
GO:0031589	cell-substrate adhesion
GO:0051260	protein homooligomerization

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum
GO:0009897	external side of plasma membrane
GO:0031012	extracellular matrix
GO:0033093	Weibel-Palade body
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001007 von Willebrand factor, type C
IPR001846 von Willebrand factor, type D domain
IPR002035 von Willebrand factor, type A
IPR002919 Trypsin Inhibitor-like, cysteine rich domain
IPR006207 Cystine knot, C-terminal
IPR006552 VWC out
IPR014853 Uncharacterised domain, cysteine-rich

PFAM

PF00093
PF00094
PF00092
PF01826
PF08742

PRINTS

PIRSF

SMART

SM00214
SM00216
SM00327
SM00041
SM00215
SM00832

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite