Version 5.4
Bos taurus Protein: NTF3
Summary
InnateDB Protein IDBP-692926.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NTF3
Protein Name Neurotrophin-3
Synonyms NT-3;
Species Bos taurus
Ensembl Protein ENSBTAP00000040469
InnateDB Gene IDBG-640643 (NTF3)
Protein Structure
UniProt Annotation
Function Seems to promote the survival of visceral and proprioceptive sensory neurons.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005165 neurotrophin receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042056 chemoattractant activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0002092 positive regulation of receptor internalization
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007274 neuromuscular synaptic transmission
GO:0007403 glial cell fate determination
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007422 peripheral nervous system development
GO:0008284 positive regulation of cell proliferation
GO:0008544 epidermis development
GO:0021675 nerve development
GO:0030335 positive regulation of cell migration
GO:0032148 activation of protein kinase B activity
GO:0032856 activation of Ras GTPase activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042490 mechanoreceptor differentiation
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048484 enteric nervous system development
GO:0048666 neuron development
GO:0048699 generation of neurons
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0050930 induction of positive chemotaxis
GO:0051145 smooth muscle cell differentiation
GO:2000251 positive regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005576 extracellular region
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID
InterPro IPR002072 Nerve growth factor-related
IPR015578 Neurotrophin-3
IPR020408 Nerve growth factor-like
IPR029034 Cystine-knot cytokine
PFAM PF00243
PRINTS PR00268
PR01914
PIRSF PIRSF001789
SMART SM00140
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q08DT3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 532393
UniGene Bt.56403
RefSeq NP_001071456
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123576
GenPept AAI23577

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca