Version 5.4
Bos taurus Protein: EDN2
Summary
InnateDB Protein IDBP-692933.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EDN2
Protein Name Endothelin-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028571
InnateDB Gene IDBG-640649 (EDN2)
Protein Structure
UniProt Annotation
Function Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in various organs including heart, lung, liver, kidney, gastrointestinal tract, uterus and ovary, but not in spleen. Within the gastrointestinal tract, gene expression was detected in rumen, a ruminant-specific digestive organ, as well as stomach, duodenum and colon. {ECO:0000269PubMed:14756425}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0001659 temperature homeostasis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0003100 regulation of systemic arterial blood pressure by endothelin
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell proliferation
GO:0010460 positive regulation of heart rate
GO:0014824 artery smooth muscle contraction
GO:0014826 vein smooth muscle contraction
GO:0019221 cytokine-mediated signaling pathway
GO:0019229 regulation of vasoconstriction
GO:0019722 calcium-mediated signaling
GO:0030593 neutrophil chemotaxis
GO:0042116 macrophage activation
GO:0042310 vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0048016 inositol phosphate-mediated signaling
GO:0048246 macrophage chemotaxis
GO:0048286 lung alveolus development
GO:0050880 regulation of blood vessel size
GO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity
GO:0097009 energy homeostasis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR001928 Endothelin-like toxin
IPR020475 Bibrotoxin/Sarafotoxin-D
PFAM PF00322
PRINTS PR00365
PIRSF
SMART SM00272
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q867A9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 319094
UniGene Bt.12942
RefSeq NP_783645
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB100737
GenPept BAC55924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca