Version 5.4
Bos taurus Protein: BRCA1
Summary
InnateDB Protein IDBP-692940.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRCA1
Protein Name breast cancer type 1 susceptibility protein homolog
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000011616
InnateDB Gene IDBG-640630 (BRCA1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 377 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 377 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044212 transcription regulatory region DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006974 cellular response to DNA damage stimulus
GO:0007098 centrosome cycle
GO:0009048 dosage compensation by inactivation of X chromosome
GO:0016567 protein ubiquitination
GO:0035066 positive regulation of histone acetylation
GO:0035067 negative regulation of histone acetylation
GO:0043009 chordate embryonic development
GO:0044030 regulation of DNA methylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051572 negative regulation of histone H3-K4 methylation
GO:0051573 negative regulation of histone H3-K9 methylation
GO:0051574 positive regulation of histone H3-K9 methylation
GO:0070512 positive regulation of histone H4-K20 methylation
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:2000620 positive regulation of histone H4-K16 acetylation
Cellular Component
GO:0000793 condensed chromosome
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001357 BRCT domain
IPR001841 Zinc finger, RING-type
IPR011364 Breast cancer type 1 susceptibility protein (BRCA1)
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF00533
PF12738
PF13639
PF14634
PF00097
PRINTS PR00493
PIRSF PIRSF001734
SMART SM00292
SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9N0H8
UniProt Splice Variant
Entrez Gene 353120
UniGene Bt.14026
RefSeq NP_848668
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AJ403968 DAAA02049201
GenPept CAB92909

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca