Version 5.4
Bos taurus Protein: CPSF4
Summary
InnateDB Protein IDBP-693101.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPSF4
Protein Name Cleavage and polyadenylation specificity factor subunit 4
Synonyms NAR;
Species Bos taurus
Ensembl Protein ENSBTAP00000002701
InnateDB Gene IDBG-640801 (CPSF4)
Protein Structure
UniProt Annotation
Function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). {ECO:0000269PubMed:9224719}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
Protein Structure and Domains
PDB ID
InterPro IPR000571 Zinc finger, CCCH-type
IPR001878 Zinc finger, CCHC-type
PFAM PF00642
PF00098
PRINTS
PIRSF
SMART SM00356
SM00343
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O19137
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 280875
UniGene Bt.55595
RefSeq NP_776367
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL U96448
GenPept AAC48759

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca