InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: VAV2

Summary

InnateDB Protein

IDBP-693152.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAV2

Protein Name

vav 2 guanine nucleotide exchange factor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005932

InnateDB Gene

IDBG-640833 (VAV2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0007264	small GTPase mediated signal transduction
GO:0010468	regulation of gene expression
GO:0016477	cell migration
GO:0030031	cell projection assembly
GO:0030032	lamellipodium assembly
GO:0030193	regulation of blood coagulation
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR000980 SH2 domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR011511 Variant SH3 domain

PFAM