InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.60919

Summary

InnateDB Protein

IDBP-693153.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.60919

Protein Name

nuclear factor NF-kappa-B p105 subunit

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027016

InnateDB Gene

IDBG-640840 (BT.60919)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 246 interaction(s) predicted by orthology.

Predicted by orthology
Total	246 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000975	regulatory region DNA binding
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0001071	nucleic acid binding transcription factor activity
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0001818	negative regulation of cytokine production
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0010956	negative regulation of calcidiol 1-monooxygenase activity
GO:0045083	negative regulation of interleukin-12 biosynthetic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050728	negative regulation of inflammatory response
GO:0071222	cellular response to lipopolysaccharide
GO:0071260	cellular response to mechanical stimulus
GO:0071316	cellular response to nicotine
GO:0071347	cellular response to interleukin-1
GO:0071354	cellular response to interleukin-6
GO:0071375	cellular response to peptide hormone stimulus
GO:0090263	positive regulation of canonical Wnt signaling pathway
GO:1900127	positive regulation of hyaluronan biosynthetic process
GO:2000630	positive regulation of miRNA metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000451 NF-kappa-B/Rel/Dorsal
IPR000488 Death domain
IPR002110 Ankyrin repeat
IPR002909 IPT domain
IPR008967 p53-like transcription factor, DNA-binding
IPR011029 Death-like domain
IPR011539 Rel homology domain
IPR014756 Immunoglobulin E-set
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00531
PF00023
PF13606
PF01833
PF00554
PF11929
PF12796

PRINTS

PR00057
PR01415

PIRSF

SMART

SM00005
SM00248
SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q5MAD5

UniProt Splice Variant

Entrez Gene

616115

UniGene

Bt.60919

RefSeq

NP_001069877

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY849381 DAAA02016773 DAAA02016774

GenPept

AAV97703