InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LHPP

Summary

InnateDB Protein

IDBP-693155.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LHPP

Protein Name

Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000047621

InnateDB Gene

IDBG-640851 (LHPP)

Protein Structure

UniProt Annotation

Function

Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency. {ECO:0000269PubMed:9448729}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in liver (at protein level). {ECO:0000269PubMed:9448729}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004427	inorganic diphosphatase activity
GO:0008969	phosphohistidine phosphatase activity
GO:0016787	hydrolase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0006796	phosphate-containing compound metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR006355 HAD-superfamily hydrolase, subfamily IIA, hypothetical 2
IPR006357 HAD-superfamily hydrolase, subfamily IIA
IPR023214 HAD-like domain

PFAM

PF13344
PF00702
PF08282
PF13419

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0VD18

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

534183

UniGene

Bt.3399

RefSeq

NP_001074381

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC119882

GenPept

AAI19883