InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ZRANB1

Summary

InnateDB Protein

IDBP-693170.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZRANB1

Protein Name

Ubiquitin thioesterase ZRANB1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004401

InnateDB Gene

IDBG-640867 (ZRANB1)

Protein Structure

UniProt Annotation

Function

Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched in punctate localization in the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding
GO:0070530	K63-linked polyubiquitin binding

Biological Process

GO:0006508	proteolysis
GO:0007010	cytoskeleton organization
GO:0016055	Wnt signaling pathway
GO:0016477	cell migration
GO:0022604	regulation of cell morphogenesis
GO:0030177	positive regulation of Wnt signaling pathway
GO:0035523	protein K29-linked deubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1990168	protein K33-linked deubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR001876 Zinc finger, RanBP2-type
IPR003323 Ovarian tumour, otubain

PFAM

PF00641
PF02338

PRINTS

PIRSF

SMART

SM00547

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QP16

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

523338

UniGene

Bt.53702

RefSeq

NP_001094584

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC149099

GenPept

AAI49100