InnateDB Protein
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IDBP-693211.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WASH1
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Protein Name
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WAS protein family homolog 1
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000015790
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InnateDB Gene
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IDBG-640903 (WASH1)
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Protein Structure
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Function |
Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. {ECO:0000250}.
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Subcellular Localization |
Early endosome membrane {ECO:0000250}. Recycling endosome membrane {ECO:0000250}. Note=Localization to the endodome membrane is mediated via its interaction with FAM21. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003124
WH2 domain
IPR021854
WASH1, WAHD domain
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PFAM |
PF02205
PF11945
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PRINTS |
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PIRSF |
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SMART |
SM00246
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TIGRFAMs |
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Modification |
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SwissProt |
A7Z063
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
533602
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UniGene |
Bt.35980
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RefSeq |
NP_001098876
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC153261
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GenPept |
AAI53262
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