InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LAMTOR3

Summary

InnateDB Protein

IDBP-693230.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMTOR3

Protein Name

Ragulator complex protein LAMTOR3

Synonyms

MAP2K1IP1; MAPKSP1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000044998

InnateDB Gene

IDBG-640925 (LAMTOR3)

Protein Structure

UniProt Annotation

Function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity). {ECO:0000250}.

Subcellular Localization

Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.

Predicted by orthology
Total	76 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0032947	protein complex scaffold

Biological Process

GO:0032006	regulation of TOR signaling
GO:0032008	positive regulation of TOR signaling
GO:0034613	cellular protein localization
GO:0043547	positive regulation of GTPase activity
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0005768	endosome
GO:0016020	membrane
GO:0031902	late endosome membrane
GO:0070062	extracellular vesicular exosome
GO:0071986	Ragulator complex

Protein Structure and Domains

PDB ID

InterPro

IPR015019 Ragulator complex protein LAMTOR3

PFAM

PF08923

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q17QQ1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

533155

UniGene

Bt.58709

RefSeq

NP_001069450

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC118239

GenPept

AAI18240