Version 5.4
Bos taurus Protein: SLC6A13
Summary
InnateDB Protein IDBP-693270.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC6A13
Protein Name Sodium- and chloride-dependent GABA transporter 2
Synonyms GAT-2;
Species Bos taurus
Ensembl Protein ENSBTAP00000019308
InnateDB Gene IDBG-640961 (SLC6A13)
Protein Structure
UniProt Annotation
Function Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005332 gamma-aminobutyric acid:sodium symporter activity
GO:0015293 symporter activity
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0015812 gamma-aminobutyric acid transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000175 Sodium:neurotransmitter symporter
IPR002981 Sodium:neurotransmitter symporter, GABA, GAT-2
PFAM PF00209
PRINTS PR00176
PR01196
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A5PJX7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 523784
UniGene Bt.56707
RefSeq NP_001092497
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC142276
GenPept AAI42277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca