Version 5.4
Bos taurus Protein: RAC1
Summary
InnateDB Protein IDBP-693334.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAC1
Protein Name Ras-related C3 botulinum toxin substrate 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012170
InnateDB Gene IDBG-641023 (RAC1)
Protein Structure
UniProt Annotation
Function Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. In pituitary cells, may mediate the activation of KCNH2 potassium channel by thyroid hormone. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up- regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3 (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Melanosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone- resorbing osteoclasts (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019899 enzyme binding
GO:0030742 GTP-dependent protein binding
GO:0031996 thioesterase binding
GO:0051022 Rho GDP-dissociation inhibitor binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002093 auditory receptor cell morphogenesis
GO:0003382 epithelial cell morphogenesis
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0006911 phagocytosis, engulfment
GO:0006972 hyperosmotic response
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0010592 positive regulation of lamellipodium assembly
GO:0015031 protein transport
GO:0016358 dendrite development
GO:0016477 cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021831 embryonic olfactory bulb interneuron precursor migration
GO:0030032 lamellipodium assembly
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0030334 regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0031529 ruffle organization
GO:0032707 negative regulation of interleukin-23 production
GO:0034446 substrate adhesion-dependent cell spreading
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043652 engulfment of apoptotic cell
GO:0045216 cell-cell junction organization
GO:0048532 anatomical structure arrangement
GO:0048813 dendrite morphogenesis
GO:0048870 cell motility
GO:0051668 localization within membrane
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060263 regulation of respiratory burst
GO:0071526 semaphorin-plexin signaling pathway
GO:0071542 dopaminergic neuron differentiation
GO:0072659 protein localization to plasma membrane
GO:0090103 cochlea morphogenesis
GO:0097178 ruffle assembly
Cellular Component
GO:0001891 phagocytic cup
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0019897 extrinsic component of plasma membrane
GO:0030027 lamellipodium
GO:0032587 ruffle membrane
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042470 melanosome
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001806 Small GTPase superfamily
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00071
PF00025
PF08477
PRINTS PR00449
PR00328
PIRSF
SMART SM00174
SM00175
SM00173
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62998
PhosphoSite PhosphoSite-
TrEMBL F1MNG3
UniProt Splice Variant
Entrez Gene 281440
UniGene
RefSeq NP_776588
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF175262 BC103061 DAAA02058341
GenPept AAF00714 AAI03062

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca