InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: WNK1

Summary

InnateDB Protein

IDBP-693361.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNK1

Protein Name

WNK lysine deficient protein kinase 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000006875

InnateDB Gene

IDBG-641017 (WNK1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.

Predicted by orthology
Total	61 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019869	chloride channel inhibitor activity
GO:0019902	phosphatase binding

Biological Process

GO:0003084	positive regulation of systemic arterial blood pressure
GO:0006468	protein phosphorylation
GO:0006811	ion transport
GO:0010923	negative regulation of phosphatase activity
GO:0035556	intracellular signal transduction
GO:0050794	regulation of cellular process
GO:0090188	negative regulation of pancreatic juice secretion

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain

PFAM

PF00069
PF07714
PF12202

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt