InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLR2D

Summary

InnateDB Protein

IDBP-69342.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLR2D

Protein Name

polymerase (RNA) II (DNA directed) polypeptide D

Synonyms

HSRBP4; HSRPB4; RBP4; RPB16;

Species

Homo sapiens

Ensembl Protein

ENSP00000272645

InnateDB Gene

IDBG-69340 (POLR2D)

Protein Structure

UniProt Annotation

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9852112}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	50 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003697	single-stranded DNA binding
GO:0003727	single-stranded RNA binding
GO:0003824	catalytic activity
GO:0003899	DNA-directed RNA polymerase activity
GO:0031369	translation initiation factor binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000398	mRNA splicing, via spliceosome
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006289	nucleotide-excision repair
GO:0006351	transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0006370	7-methylguanosine mRNA capping
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016032	viral process
GO:0031990	mRNA export from nucleus in response to heat stress
GO:0034402	recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
GO:0044237	cellular metabolic process
GO:0045948	positive regulation of translational initiation
GO:0050434	positive regulation of viral transcription