Version 5.4
Bos taurus Protein: MEAF6
Summary
InnateDB Protein IDBP-693542.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEAF6
Protein Name Chromatin modification-related protein MEAF6
Synonyms C1orf149; C3H1orf149;
Species Bos taurus
Ensembl Protein ENSBTAP00000052635
InnateDB Gene IDBG-641204 (MEAF6)
Protein Structure
UniProt Annotation
Function Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleolus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
GO:0043968 histone H2A acetylation
GO:0043981 histone H4-K5 acetylation
GO:0043982 histone H4-K8 acetylation
GO:0043983 histone H4-K12 acetylation
GO:0044154 histone H3-K14 acetylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0035267 NuA4 histone acetyltransferase complex
GO:0070776 MOZ/MORF histone acetyltransferase complex
Protein Structure and Domains
PDB ID
InterPro IPR015418 Histone H4 acetyltransferase, NuA4 complex, Eaf6
PFAM PF09340
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q58CU0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 540599
UniGene Bt.70024
RefSeq XP_005204892
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BT021857 DV808321
GenPept AAX46704

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca