InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: LAP3

Summary

InnateDB Protein

IDBP-693559.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAP3

Protein Name

Cytosol aminopeptidase

Synonyms

LAP-3; PEPS;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000007860

InnateDB Gene

IDBG-641216 (LAP3)

Protein Structure

UniProt Annotation

Function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0008233	peptidase activity
GO:0008235	metalloexopeptidase activity
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0019538	protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000819 Peptidase M17, leucyl aminopeptidase, C-terminal
IPR008283 Peptidase M17, leucyl aminopeptidase, N-terminal
IPR011356 Leucine aminopeptidase/peptidase B

PFAM

PF00883
PF02789

PRINTS

PR00481

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P00727