InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SLIT2

Summary

InnateDB Protein

IDBP-693597.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLIT2

Protein Name

slit homolog 2 (Drosophila)

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000053607

InnateDB Gene

IDBG-641256 (SLIT2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005095	GTPase inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043237	laminin-1 binding
GO:0043394	proteoglycan binding
GO:0045499	chemorepellent activity
GO:0048495	Roundabout binding

Biological Process

GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0001933	negative regulation of protein phosphorylation
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0002689	negative regulation of leukocyte chemotaxis
GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0008045	motor neuron axon guidance
GO:0008285	negative regulation of cell proliferation
GO:0010593	negative regulation of lamellipodium assembly
GO:0010596	negative regulation of endothelial cell migration
GO:0010629	negative regulation of gene expression
GO:0014912	negative regulation of smooth muscle cell migration
GO:0016337	single organismal cell-cell adhesion
GO:0021772	olfactory bulb development
GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration
GO:0021972	corticospinal neuron axon guidance through spinal cord
GO:0022029	telencephalon cell migration
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0030837	negative regulation of actin filament polymerization
GO:0031290	retinal ganglion cell axon guidance
GO:0032870	cellular response to hormone stimulus
GO:0033563	dorsal/ventral axon guidance
GO:0043065	positive regulation of apoptotic process
GO:0043086	negative regulation of catalytic activity
GO:0043116	negative regulation of vascular permeability
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048812	neuron projection morphogenesis
GO:0048846	axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0050929	induction of negative chemotaxis
GO:0051058	negative regulation of small GTPase mediated signal transduction
GO:0051414	response to cortisol
GO:0060603	mammary gland duct morphogenesis
GO:0060763	mammary duct terminal end bud growth
GO:0061364	apoptotic process involved in luteolysis
GO:0070100	negative regulation of chemokine-mediated signaling pathway
GO:0071504	cellular response to heparin
GO:0071672	negative regulation of smooth muscle cell chemotaxis
GO:0071676	negative regulation of mononuclear cell migration
GO:0090024	negative regulation of neutrophil chemotaxis
GO:0090260	negative regulation of retinal ganglion cell axon guidance
GO:0090288	negative regulation of cellular response to growth factor stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000742 Epidermal growth factor-like domain
IPR001611 Leucine-rich repeat
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR003591 Leucine-rich repeat, typical subtype
IPR003645 Follistatin-like, N-terminal
IPR006207 Cystine knot, C-terminal
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM