Bos taurus Protein: EIF3B | |||||||||||||||
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Summary | |||||||||||||||
InnateDB Protein | IDBP-693667.2 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | EIF3B | ||||||||||||||
Protein Name | Eukaryotic translation initiation factor 3 subunit B | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Protein | ENSBTAP00000009832 | ||||||||||||||
InnateDB Gene | IDBG-641311 (EIF3B) | ||||||||||||||
Protein Structure | |||||||||||||||
UniProt Annotation | |||||||||||||||
Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (By similarity). {ECO:0000250}. | ||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000255HAMAP-Rule:MF_03001}. | ||||||||||||||
Disease Associations | |||||||||||||||
Tissue Specificity | |||||||||||||||
Comments | |||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||
PDB ID | |||||||||||||||
InterPro |
IPR000504
RNA recognition motif domain IPR011400 Eukaryotic translation initiation factor 3 subunit B IPR013979 Translation initiation factor, beta propellor-like domain |
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PFAM |
PF00076
PF08662 |
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PRINTS | |||||||||||||||
PIRSF |
PIRSF036424
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SMART |
SM00360
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TIGRFAMs | |||||||||||||||
Post-translational Modifications | |||||||||||||||
Modification | |||||||||||||||
Cross-References | |||||||||||||||
SwissProt | A7MB16 | ||||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | 789999 | ||||||||||||||
UniGene | Bt.55760 | ||||||||||||||
RefSeq | NP_001095826 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | BC151284 | ||||||||||||||
GenPept | AAI51285 | ||||||||||||||