InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PPARGC1A

Summary

InnateDB Protein

IDBP-693672.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPARGC1A

Protein Name

Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000022636

InnateDB Gene

IDBG-641316 (PPARGC1A)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0003723	RNA binding
GO:0031490	chromatin DNA binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010822	positive regulation of mitochondrion organization
GO:0010941	regulation of cell death
GO:0014850	response to muscle activity
GO:0022904	respiratory electron transport chain
GO:0032922	circadian regulation of gene expression
GO:0034599	cellular response to oxidative stress
GO:0042752	regulation of circadian rhythm
GO:0043524	negative regulation of neuron apoptotic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048511	rhythmic process
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070997	neuron death
GO:2000507	positive regulation of energy homeostasis
GO:2001171	positive regulation of ATP biosynthetic process