InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NDUFA13

Summary

InnateDB Protein

IDBP-693683.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFA13

Protein Name

NADH dehydrogenase

Synonyms

GRIM19;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010276

InnateDB Gene

IDBG-641334 (NDUFA13)

Protein Structure

UniProt Annotation

Function

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) cell death pathway. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}; Matrix side {ECO:0000305}. Nucleus. Note=May be translocated into the nucleus upon IFN/RA treatment. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity

Biological Process

GO:0006915	apoptotic process
GO:0030308	negative regulation of cell growth
GO:0045892	negative regulation of transcription, DNA-templated
GO:0055114	oxidation-reduction process
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005746	mitochondrial respiratory chain
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070469	respiratory chain

Protein Structure and Domains

PDB ID

InterPro

IPR009346 GRIM-19

PFAM

PF06212

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q95KV7

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

338084

UniGene

Bt.49187

RefSeq

NP_788845

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AJ316011 BC102406

GenPept

AAI02407 CAC87049