InnateDB Protein
|
IDBP-693686.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
MAPT
|
Protein Name
|
Microtubule-associated protein tau
|
Synonyms
|
tau;
|
Species
|
Bos taurus
|
Ensembl Protein
|
ENSBTAP00000054412
|
InnateDB Gene
|
IDBG-641321 (MAPT)
|
Protein Structure
|
|
Function |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
|
Subcellular Localization |
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
|
Disease Associations |
|
Tissue Specificity |
Expressed in neurons.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 61 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
8
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
61 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001084
Microtubule associated protein, tubulin-binding repeat
IPR002955
Microtubule-associated protein Tau
|
PFAM |
PF00418
|
PRINTS |
PR01261
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P29172
|
PhosphoSite |
PhosphoSite-P29172
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
281296
|
UniGene |
|
RefSeq |
|
HUGO |
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
BC109941
L34940
L34941
L34942
L34943
L34944
L34946
L34947
L34948
L34949
L34950
L34951
L34952
L34953
M26157
M26158
M26178
|
GenPept |
AAA30770
AAA30771
AAA51601
AAA51602
AAA51603
AAA51604
AAA51605
AAA51606
AAA51609
AAI09942
|
|
|