Version 5.4
Bos taurus Protein: PSMF1
Summary
InnateDB Protein IDBP-693789.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSMF1
Protein Name Proteasome inhibitor PI31 subunit
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024505
InnateDB Gene IDBG-641425 (PSMF1)
Protein Structure
UniProt Annotation
Function Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0070628 proteasome binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:1901799 negative regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR013886 PI31 proteasome regulator
IPR021625 Fbxo7/PI31 domain
PFAM PF08577
PF11566
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SX30
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 617807
UniGene
RefSeq NP_001069946
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104535 BT025365
GenPept AAI04536 ABF57321

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca