Version 5.4
Bos taurus Protein: TBC1D20
Summary
InnateDB Protein IDBP-693824.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBC1D20
Protein Name TBC1 domain family member 20
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000017725
InnateDB Gene IDBG-641461 (TBC1D20)
Protein Structure
UniProt Annotation
Function GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
GO:0005097 Rab GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0001675 acrosome assembly
GO:0002088 lens development in camera-type eye
GO:0007030 Golgi organization
GO:0007283 spermatogenesis
GO:0008584 male gonad development
GO:0032313 regulation of Rab GTPase activity
GO:0032851 positive regulation of Rab GTPase activity
GO:0034389 lipid particle organization
GO:0043010 camera-type eye development
GO:0043547 positive regulation of GTPase activity
GO:0070309 lens fiber cell morphogenesis
GO:0072520 seminiferous tubule development
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000195 Rab-GTPase-TBC domain
PFAM PF00566
PRINTS
PIRSF
SMART SM00164
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2T9Q1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 504543
UniGene Bt.13795
RefSeq NP_001033118
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111319
GenPept AAI11320

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca