InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: EIF3L

Summary

InnateDB Protein

IDBP-693899.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EIF3L

Protein Name

Eukaryotic translation initiation factor 3 subunit L

Synonyms

EIF3EIP; EIF3S6IP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014281

InnateDB Gene

IDBG-641520 (EIF3L)

Protein Structure

UniProt Annotation

Function

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000255HAMAP- Rule:MF_03011}.

Subcellular Localization

Cytoplasm {ECO:0000255HAMAP-Rule:MF_03011}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001731	formation of translation preinitiation complex
GO:0006412	translation
GO:0006413	translational initiation
GO:0006446	regulation of translational initiation

Cellular Component

GO:0001650	fibrillar center
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005852	eukaryotic translation initiation factor 3 complex
GO:0016020	membrane
GO:0016282	eukaryotic 43S preinitiation complex
GO:0033290	eukaryotic 48S preinitiation complex

Protein Structure and Domains

PDB ID

InterPro

IPR019382 Translation initiation factor 3 complex subunit L

PFAM

PF10255

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZCK1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

514449

UniGene

Bt.49273

RefSeq

NP_001030373

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102112

GenPept

AAI02113