Version 5.4
Bos taurus Protein: CBY1
Summary
InnateDB Protein IDBP-694051.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CBY1
Protein Name Protein chibby homolog 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008651
InnateDB Gene IDBG-641671 (CBY1)
Protein Structure
UniProt Annotation
Function Inhibits the Wnt/Wingless pathway by binding to beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus speckle {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Note=Nuclear, in a punctate manner. Also found in the trans-Golgi (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0042802 identical protein binding
Biological Process
GO:0008104 protein localization
GO:0030154 cell differentiation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0042384 cilium assembly
GO:0045444 fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0055007 cardiac muscle cell differentiation
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016607 nuclear speck
GO:0036064 ciliary basal body
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8MJK1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282859
UniGene Bt.17918
RefSeq NP_777164
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF393210 BC120055
GenPept AAI20056 AAM73678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca