Version 5.4
Bos taurus Protein: ISYNA1
Summary
InnateDB Protein IDBP-694097.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISYNA1
Protein Name Inositol-3-phosphate synthase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023241
InnateDB Gene IDBG-641701 (ISYNA1)
Protein Structure
UniProt Annotation
Function Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004512 inositol-3-phosphate synthase activity
GO:0016853 isomerase activity
Biological Process
GO:0006021 inositol biosynthetic process
GO:0006629 lipid metabolic process
GO:0008654 phospholipid biosynthetic process
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002587 Myo-inositol-1-phosphate synthase
IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like
PFAM PF07994
PF01658
PRINTS
PIRSF PIRSF015578
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2NL29
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509394
UniGene Bt.59123
RefSeq NP_001039497
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111160
GenPept AAI11161

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca