Version 5.4
Bos taurus Protein: RAB3A
Summary
InnateDB Protein IDBP-694142.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB3A
Protein Name Ras-related protein Rab-3A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014062
InnateDB Gene IDBG-641746 (RAB3A)
Protein Structure
UniProt Annotation
Function Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Disease Associations
Tissue Specificity Specifically expressed in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0003016 respiratory system process
GO:0006184 GTP catabolic process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0006913 nucleocytoplasmic transport
GO:0007005 mitochondrion organization
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007274 neuromuscular synaptic transmission
GO:0007409 axonogenesis
GO:0009791 post-embryonic development
GO:0015031 protein transport
GO:0016079 synaptic vesicle exocytosis
GO:0016188 synaptic vesicle maturation
GO:0017157 regulation of exocytosis
GO:0030324 lung development
GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane
GO:0048790 maintenance of presynaptic active zone structure
GO:0050975 sensory perception of touch
GO:0051602 response to electrical stimulus
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00071
PF00025
PF04670
PF08477
PF09439
PRINTS PR00449
PR00627
PR00328
PIRSF
SMART SM00176
SM00174
SM00175
SM00173
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P11023
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282029
UniGene Bt.2362
RefSeq NP_776871
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC118278 M19885
GenPept AAA30416 AAI18279

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca