Version 5.4
Bos taurus Protein: CHORDC1
Summary
InnateDB Protein IDBP-694149.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHORDC1
Protein Name Cysteine and histidine-rich domain-containing protein 1
Synonyms CHP-1;
Species Bos taurus
Ensembl Protein ENSBTAP00000018100
InnateDB Gene IDBG-641747 (CHORDC1)
Protein Structure
UniProt Annotation
Function Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0051879 Hsp90 protein binding
Biological Process
GO:0006950 response to stress
GO:0010824 regulation of centrosome duplication
GO:0061077 chaperone-mediated protein folding
GO:1900034 regulation of cellular response to heat
GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR007051 Cysteine/histidine-rich domain
IPR007052 CS domain
IPR008978 HSP20-like chaperone
PFAM PF04968
PF04969
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q29RL2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 505144
UniGene Bt.9105
RefSeq NP_001039377
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114125
GenPept AAI14126

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca