Version 5.4
Bos taurus Protein: SNTA1
Summary
InnateDB Protein IDBP-694221.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNTA1
Protein Name Alpha-1-syntrophin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000662
InnateDB Gene IDBG-641818 (SNTA1)
Protein Structure
UniProt Annotation
Function Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5- bisphosphate (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Predicted by orthology
Total 63 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0017080 sodium channel regulator activity
GO:0044325 ion channel binding
GO:0050998 nitric-oxide synthase binding
GO:0051117 ATPase binding
Biological Process
GO:0002027 regulation of heart rate
GO:0003117 regulation of vasoconstriction by circulating norepinephrine
GO:0007528 neuromuscular junction development
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0086005 ventricular cardiac muscle cell action potential
GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation
GO:1902305 regulation of sodium ion transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030054 cell junction
GO:0042383 sarcolemma
GO:0043234 protein complex
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR001478 PDZ domain
IPR001849 Pleckstrin homology domain
PFAM PF00595
PF13180
PF00169
PRINTS
PIRSF
SMART SM00228
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0P5E6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 527488
UniGene Bt.27627
RefSeq NP_001069366
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120146
GenPept AAI20147

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca