InnateDB Protein
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IDBP-694281.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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UCHL1
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Protein Name
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Ubiquitin carboxyl-terminal hydrolase isozyme L1
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000044075
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InnateDB Gene
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IDBG-641874 (UCHL1)
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Protein Structure
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Function |
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Endoplasmic reticulum membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Neurons and cells of the diffuse neuroendocrine system and their tumors.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
50 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001578
Peptidase C12, ubiquitin carboxyl-terminal hydrolase
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PFAM |
PF01088
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PRINTS |
PR00707
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P23356
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
514394
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UniGene |
Bt.58848
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RefSeq |
NP_001039637
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC111330
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GenPept |
AAI11331
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