InnateDB Protein
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IDBP-694286.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ASIP
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Protein Name
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Agouti-signaling protein
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000045382
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InnateDB Gene
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IDBG-641881 (ASIP)
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Protein Structure
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Function |
Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR007733
Agouti
IPR027300
Agouti domain
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PFAM |
PF05039
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PRINTS |
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PIRSF |
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SMART |
SM00792
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TIGRFAMs |
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Modification |
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SwissProt |
Q29414
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q06W02
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UniProt Splice Variant |
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Entrez Gene |
404192
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UniGene |
Bt.89130
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RefSeq |
NP_996674
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AY348953
AY348954
AY352659
BC102291
DQ494381
X99691
X99692
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GenPept |
AAI02292
AAQ56605
ABF50192
CAA68003
CAA68004
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