Version 5.4
Bos taurus Protein: L3MBTL2
Summary
InnateDB Protein IDBP-694287.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol L3MBTL2
Protein Name Lethal(3)malignant brain tumor-like protein 2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000037474
InnateDB Gene IDBG-641878 (L3MBTL2)
Protein Structure
UniProt Annotation
Function Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.
Predicted by orthology
Total 46 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
GO:0042393 histone binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR004092 Mbt repeat
IPR012313 Zinc finger, FCS-type
PFAM PF02820
PRINTS
PIRSF
SMART SM00561
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1JQD9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 513297
UniGene Bt.26574
RefSeq NP_001069078
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116013 BT026170
GenPept AAI16014 ABG67009

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca