Version 5.4
Bos taurus Protein: INSL3
Summary
InnateDB Protein IDBP-694303.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INSL3
Protein Name Insulin-like 3Insulin-like 3 B' chainInsulin-like 3 B chainInsulin-like 3 A chain
Synonyms RLF;
Species Bos taurus
Ensembl Protein ENSBTAP00000027848
InnateDB Gene IDBG-641896 (INSL3)
Protein Structure
UniProt Annotation
Function Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed exclusively in Leydig cells of the testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005179 hormone activity
Biological Process
GO:0001701 in utero embryonic development
GO:0008584 male gonad development
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR016179 Insulin-like
PFAM PF00049
PRINTS
PIRSF
SMART SM00078
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O77801
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281870
UniGene Bt.91145
RefSeq NP_776790
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF094580 BC102547
GenPept AAC63380 AAI02548

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca