Version 5.4
Bos taurus Protein: MAP1LC3A
Summary
InnateDB Protein IDBP-694315.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP1LC3A
Protein Name Microtubule-associated proteins 1A/1B light chain 3A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008072
InnateDB Gene IDBG-641905 (MAP1LC3A)
Protein Structure
UniProt Annotation
Function Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=LC3-II binds to the autophagic membranes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.
Predicted by orthology
Total 92 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008429 phosphatidylethanolamine binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0000422 mitochondrion degradation
GO:0006914 autophagy
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005737 cytoplasm
GO:0005776 autophagic vacuole
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0031090 organelle membrane
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID
InterPro IPR004241 Autophagy protein Atg8 ubiquitin like
IPR007242 Ubiquitin-like protein Atg12
IPR029071 Ubiquitin-related domain
PFAM PF02991
PF04110
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2HJ23
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 514547
UniGene Bt.8073
RefSeq NP_001039640
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113348
GenPept AAI13349

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca