InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GUF1

Summary

InnateDB Protein

IDBP-694377.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUF1

Protein Name

Translation factor GUF1, mitochondrial

Synonyms

EF-4;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000356

InnateDB Gene

IDBG-641965 (GUF1)

Protein Structure

UniProt Annotation

Function

Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. {ECO:0000255HAMAP-Rule:MF_03137}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000255HAMAP-Rule:MF_03137}; Peripheral membrane protein {ECO:0000255HAMAP-Rule:MF_03137}; Matrix side {ECO:0000255HAMAP- Rule:MF_03137}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0016787	hydrolase activity
GO:0043022	ribosome binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006412	translation
GO:0007264	small GTPase mediated signal transduction
GO:0045727	positive regulation of translation

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000640 Translation elongation factor EFG, V domain
IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005225 Small GTP-binding protein domain
IPR006297 Elongation factor 4
IPR009000 Translation protein, beta-barrel domain
IPR009022 Elongation factor G, III-V domain
IPR013842 GTP-binding protein LepA, C-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00679
PF00009
PF00071
PF03144
PF14492
PF06421

PRINTS

PR00315
PR00449

PIRSF

SMART

SM00838

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A6QLJ3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

522459

UniGene

Bt.103039

RefSeq

NP_001095537

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC147985

GenPept

AAI47986