InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BABAM1

Summary

InnateDB Protein

IDBP-694506.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BABAM1

Protein Name

BRISC and BRCA1-A complex member 1

Synonyms

C19orf62; C7H19orf62; MERIT40;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000044652

InnateDB Gene

IDBG-642089 (BABAM1)

Protein Structure

UniProt Annotation

Function

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes at sites of DNA damage at double- strand breaks (DSBs). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.

Predicted by orthology
Total	52 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006974	cellular response to DNA damage stimulus
GO:0010212	response to ionizing radiation
GO:0016568	chromatin modification
GO:0031572	G2 DNA damage checkpoint
GO:0045739	positive regulation of DNA repair
GO:0070536	protein K63-linked deubiquitination

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070531	BRCA1-A complex
GO:0070552	BRISC complex

Protein Structure and Domains

PDB ID

InterPro

IPR002035 von Willebrand factor, type A

PFAM

PF00092

PRINTS

PIRSF

SMART

SM00327

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08E57

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

504517

UniGene

Bt.22247

RefSeq

NP_001070269

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123408

GenPept

AAI23409